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Literatur über Inhaltsstoffe von Laminaria spec.

In der folgenden Auflistung finden Sie Literatur zusammengestellt, die in einen kleinen Einblick geben soll, wieviel bereits an Algenwirkstoffen geforscht wird.

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Aguilera J., Dummermuth A., Karsten u., Schriek R., Wiencke Ch. (2002) Enzymatic defences against photooxidative stress induced by ultraviolet radiation in Arctic marine macroalgae, Polar biology 2002, vol. 25, no 6, pp. 432-441


Aquaron R., Delange F., Marchal P., Lognoné V., Ninane L. (2002) Bioavailability of seaweed iodine in human beings., Cell Mol Biol (Noisy-le-grand). 2002 Jul;48(5):563-9

As an important fraction of consumers in the world prefers natural products over artificial ones, we investigated the industrial feasibility of naturally iodized salt using seaweed as source of iodine.

 

Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Untersuchungsergebnisse 2008: Jod- und Schwermetallgehalte in algenhaltigen Kosmetika

 

Bilan M.I., Grachev A.A., Shashkov A.S., Kelly M., Sanderson C.J., Nifantiev N.E., Usov A.I. (2010) Further studies on the composition and structure of a fucoidan preparation from the brown alga Saccharina latissima., Carbohydr Res. Vol. 345(14):2038-47.

In accordance with the previous data, the main polysaccharide component was shown to be a fucan sulfate [...]. In addition, three other types of sulfated polysaccharide molecules were detected in the total fucoidan preparation [...].

 

Brunschweiger E.-M., Pharmakologische Wirkung von Meerwasser, in: Schleswig-Holsteinisches Ärzteblatt 6/2005, S. 68-72


Bundesamt für Risikobewertung (BfR), Gesundheitliche Risiken durch zu hohen Jodgehalt in getrockneten Algen, aktualisierte Stellungnahme Nr. 026/2007 des BfR vom 22. Juni 2004


Bund/Länder-Messprogramm Meeresumwelt (BLMP), 2005: Zustandsbericht 1999–2002 für Nordsee und Ostsee

 

Croci D.O., Cumashi A., Ushakova N.A., Preobrazhenskaya M.E., Piccoli A., Totani L., Ustyuzhanina N.E., Bilan M.I., Usov A.I., Grachev A.A., Morozevich G.E., Berman A.E., Sanderson C.J., Kelly M., Di Gregorio P., Rossi C., Tinari N., Iacobelli S., Rabinovich G.A., Nifantiev N.E. (2011) Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides from Laminaria saccharina Brown Seaweed., PLoS One. 6(2):e17283.

Thus, sulfated fucans are mainly responsible for the anti-inflammatory, anticoagulant, antiangiogenic, and antitumor activities of sulfated polysaccharides from L. saccharina brown seaweed.

 

Cumashi A, Ushakova NA, Preobrazhenskaya ME, D'Incecco A, Piccoli A, Totani L, Tinari N, Morozevich GE, Berman AE, Bilan MI, Usov AI, Ustyuzhanina NE, Grachev AA, Sanderson CJ, Kelly M, Rabinovich GA, Iacobelli S, Nifantiev NE (2007) A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds., Glycobiology vol. 17 no. 5 pp. 541–552

All fucoidans inhibited leucocyte recruitment in an inflammation model in rats, and neither the content of fucose and sulfate nor other structural features of their polysaccharide backbones significantly affected the efficacy of fucoidans in this model.


Davis T.A., Voleskya B., Mucci A. (2003) A review of the biochemistry of heavy metal biosorption by brown algae., Water Research 37 (2003) 4311–4330

More specifically, it is the properties of cell wall constituents, such as alginate and fucoidan, which are chiefly responsible for heavy metal chelation.


Dawczynski Ch., Schubert R., Jahreis G. (2006) Amino acids, fatty acids, and diatary fible in edible seaweed products, Food Chemistry 103 (2007) 891-899

Interestingly, the FA distribution of seaweed products showed high levels of n-3 FA and demonstrated a nutritionally ideal n-6/n-3 FA ratio. The predominante FA in various seaweed products was eicosapentaenoic acid (C20:5,n-3) which was at concentrations as high as 50% of total FA content.


Dawczynski C., Schäfer U., Leiterer M., Jahreis G. (2007) Nutritional and toxicological importance of macro, trace, and ultra-trace elements in algae food products., J Agric Food Chem. 2007 Dec 12;55(25):10470-5


Douady D., Rousseau B., Caron L. (1994) Fucoxanthin-chlorophyll a/c light-harvesting complexes of Laminaria saccharina: partial amino acid sequences and arrangement in thylakoid membranes., Biochemistry. 1994 Mar 22;33(11):3165-70


Drozd N.N., Tolstenkov A.S., Makarov V.A., Kuznetsova T.A., Besednova N.N., Shevchenko N.M., Zvyagintseva T.N. (2006) Pharmacodynamic parameters of anticoagulants based on sulfated polysaccharides from marine algae., Bull Exp Biol Med. 2006 Nov;142(5):591-3


Fodil-Bourahla I, Bizbiz L, Schoevaert D, Robert AM, Robert L. (2003) Effect of L-fucose and fucose-rich oligo- and polysaccharides (FROP-s) on skin aging: penetration, skin tissue production and fibrillogenesis., Biomed Pharmacother. 2003 Jul-Aug;57(5-6):209-15

These results, together with the previous favorable activities on the downregulation of matrix-degrading enzymes, free radical scavenging and increased cell proliferation confirm the favorable action of fucose and fucose-rich polysaccharides (FROP-s) on the skin by slowing down its aging.


Fujimura T., Tsukahara K., Moriwaki S., Kitahara T., Sano T., Takema Y. (2002) Treatment of human skin with an extract of Fucus vesiculosus chanoes its thickness and mechanical properties, J. Cosmet. Sci., 53, 1-9

In this study, they investigated the effects of topical application of an aqueous extract of this alga on the thickness and the mechanical properties of human skin. [...] These results suggest that the Fucm vesiculosus extract possesses anti-aging activities and should be useful for a variety of cosmetics.


Guiry M.D. and Blunden G. (1991) Seaweed Ressources in Europe: Uses and Potential


Han J., Kang S., Choue R., Kim H., Leem K., Chung S., Kim C., Chung J. (2002) Free radical scavenging effect of Diospyros kaki, Laminaria japonica and Undaria pinnatifida., Fitoterapia. 2002 Dec;73(7-8):710-2


Isnard N, Fodil-Bourahla I, Robert AM, Robert L. (2004) Pharmacology of skin aging. Stimulation of glycosaminoglycan biosynthesis by L-fucose and fucose-rich polysaccharides, effect of in vitro aging of fibroblasts., Biomed Pharmacother. 2004 Apr;58(3):202-4

These stimulations of GAG-biosynthesis might play a role in the increase of total skin thickness of hairless rats treated with L-fucose, as well as in several other favorable results recorded for FROP-3 such as the increased hydration (resistance to pressure) and elasticity of human skin


Jin D.Q., Li G., Kim J.S., Yong C.S., Kim J.A., Huh K. (2004) Preventive effects of Laminaria japonica aqueous extract on the oxidative stress and xanthine oxidase activity in streptozotocin-induced diabetic rat liver., Biol Pharm Bull. 2004 Jul;27(7):1037-40

The results suggest that Laminaria japonica would be of great value in preventing hyper-glycemia in diabetes mellitus as a dietary supplement possibly, through its antioxidant activity.


Kim K.H., Kim Y.W., Kim H.B., Lee B.J., Lee D.S. (2006) Anti-apoptotic activity of laminarin polysaccharides and their enzymatically hydrolyzed oligosaccharides from Laminaria japonica., Biotechnol Lett. 2006 Mar;28(6):439-46

These results suggest that laminarin oligosaccharides and polysaccharides can be utilized to develop new immunopotentiating substances and functional alternative medicines.


Küpper F.C., Carpenter L.J., McFiggans G.B., Palmer C.J., Waite T.J., Boneberg E.M., Woitsch S., Weiller M., Abela R., Grolimund D., Potin P., Butler A., Luther G.W. 3rd, Kroneck P.M., Meyer-Klaucke W., Feiters M.C. (2008) Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry., Proc Natl Acad Sci U S A. 2008 May 13;105(19):6954-8

Using x-ray absorption spectroscopy, we show that the accumulated form is iodide, which readily scavenges a variety of reactive oxygen species (ROS). We propose here that its biological role is that of an inorganic antioxidant, the first to be described in a living system. ... In a complementary set of experiments using a heterologous system, iodide was found to effectively scavenge ROS in human blood cells.


Li N, Zhang Q, Song J (2005) Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats., Food Chem Toxicol. 2005 Mar; 43(3):421-6

The results showed that no significant toxicological changes were observed when 300 mg/kg body weight per day fucoidan was administered to rats.


Neyrinck A.M., Mouson A., Delzenne N.M. (2007) Dietary supplementation with laminarin, a fermentable marine beta (1-3) glucan, protects against hepatotoxicity induced by LPS in rat by modulating immune response in the hepatic tissue., Int Immunopharmacol. 2007 Dec 5;7(12):1497-506 , Comment in: Int Immunopharmacol. 2008 Mar;8(3):514-5; discussion 516-7


Nishide E., Anzai H., Uchida N. and Nisizawa K. (1990) Sugar constituents of fucose-containing polysaccharides from various Japanese brown algae., Hydrobiologia Vol. 204-205, No. 1


Passaquet C., Thomas J.C., Caron L., Hauswirth N., Puel F., Berkaloff C. (1991) Light-harvesting complexes of brown algae. Biochemical characterization and immunological relationships., FEBS Lett. 1991 Mar 11;280(1):21-6


Péterszegi G, Robert AM, Robert L. (2003) Protection by L-fucose and fucose-rich polysaccharides against ROS-produced cell death in presence of ascorbate., Biomed Pharmacother. 2003 May-Jun;57(3-4):130-3

It appeared that relatively low concentrations of L-fucose and FROP-3 (Biomed. Pharmacother. in press) could efficiently protect fibroblasts from the ascorbate-induced cell-death. These novel pharmacological properties of L-fucose and FROP-3 might well be related to their accelerating effect of wound healing.


Robert L, Fodil-Bourahla I, Bizbiz L, Robert AM. (2004) Effect of L-fucose and fucose-rich polysaccharides on elastin biosynthesis, in vivo and in vitro., Biomed Pharmacother. 2004 Mar;58(2):123-8

These results show that L-fucose and FROP-3 stimulate tropoelastin biosynthesis in vitro, and elastic fibre formation in vivo.


Sánchez-Machado D.I., López-Hernández J., Paseiro-Losada P., López-Cervantes J. (2004) An HPLC method for the quantification of sterols in edible seaweeds., Biomed Chromatogr. 2004 Apr;18(3):183-90

The predominant sterol was fucosterol in brown seaweeds (83-97% of total sterol content)


Senni K., Gueniche F., Foucault-Bertaud A., Igondjo-Tchen S., Fioretti F., Colliec-Jouault S., Durand P., Guezennec J., Godeau G., Letourneur D. (2006) Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis., Arch Biochem Biophys. 2006 Jan 1;445(1):56-64.

Using tissue sections of human skin in ex vivo experiments, we evidenced that this polysaccharide was able to minimize human leukocyte elastase activity resulting in the protection of human skin elastic fiber network against the enzymatic proteolysis due to this serine proteinase.


Stengel D.B., Macken A., Morrison L., Morley N. (2004) Zinc concentrations in marine macroalgae and a lichen from western Ireland in relation to phylogenetic grouping, habitat and morphology., Mar Pollut Bull. 2004 May;48(9-10):902-9


Sugawara T., Matsubara K., Akagi R., Mori M., Hirata T. (2006) Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol., J Agric Food Chem. 2006 Dec 27;54(26):9805-10


Usov A.I. ; Smirnova g.p. ; Bilan M.I. ; Shashkov A.S. (1998) Polysaccharides of Algae. 53. Brown Alga Laminaria saccharina (L.) Lam. as a Source of Fucoidan , Russ J Bioorgan Chem (1998) 24:437–445.

Fucoidan was found to contain L-fucose and sulfate as major components and galactose, xylose, and glucuronic acid as minor components.


Voronova Y.G., Rekhina N.I., Nikolaeva T.A., Tiunova N.A., Zailina I.V., Kobzeva N.YA., Valiente O. (2006) Extraction of carbohydrates from Laminaria and their utilization, Journal of Applied Phycology (2006) Vol. 3, No. 3


Wang J., Zhang Q., Zhang Z., Li Z. (2008) Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica., Int J Biol Macromol. 2008 Mar 1;42(2):127-32

The correlation between the sulfate content and scavenging superoxide radical ability was positive. Available data obtained with in vitro models suggested that the ratio of sulfate content/fucose was an effective indicator to antioxidant activity of the samples.


Xue Chang-Hu, Yu Fang, Hong Lin, Lei Chen, Li Zhao-Jie, Deng Deng, Lu Chong-Xiao (2001) Chemical characters and antioxidative properties of sulfated polysaccharides from Laminaria japonica, Journal of Applied Phycology (2001) Vol. 13, No. 1


Yan X., Zheng L., Chen H., Lin W., Zhang W. (2004) Enriched accumulation and biotransformation of selenium in the edible seaweed Laminaria japonica., J Agric Food Chem. 2004 Oct 20;52(21):6460-4

This implied that kelp L. japonica could effectively transform inorganic selenium into organic selenium through metabolism.


Yuan Y.V., Walsh N.A. (2006) Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds, Food and Chemical Toxicology 44 (2006) 1144-1150


Zvyagintseva T.N., Shevchenko N.M., Nazarova I.V., Scobun A.S., Luk'yanov P.A., Elyakova L.A. (2000) Inhibition of complement activation by water-soluble polysaccharides of some far-eastern brown seaweeds., Comp Biochem Physiol C Toxicol Pharmacol. 2000 Jul;126(3):209-15

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